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Researchers, politicians and funding bodies find themselves in front of a unique situation and enormous challenge: The mounting pressure to accelerate and intensify efforts to tackle the COVID pandemic while handling the growing threat from all other diseases endangering our society. Cancer patients are particularly at risk for infections because of their disease and its treatment. Latest News. Scientists from the German Cancer Research Center and from University Hospital Heidelberg and University medicine Mannheim have now established that a signaling pathway that prevents this step is stimulated in obese mice, hence promoting insulin resistance. This allows scientists to obtain specific cell types for their research. ERC Grants. One of the main features of colorectal cancer is that there are considerable differences between the tumors of individual patients - at genetic level and hence in terms of the response to treatment too. Each laboratory is designed around the safety level of its research, including the laboratory equipment, the specific working practices, and the typical protective equipment worn. This is particularly true in the case of malignant melanoma. Current Topic. We are asking for your support Your Donation for Cancer Research. Researchers from the German Cancer Consortium DKTK have developed a method that allows these differences to be identified more effectively. Brain tumors in children. In further investigations in mice, the researchers demonstrated that tumor cells that produce angiopoietin-2 are protected against cell stress and thus have an advantage in metastasis. While the phenomenon was previously considered to be rather rare, scientists at the German Cancer Research Center have now shown that chromothripsis is detectable in almost half of all tumors. Daily work routine of our more than 1, scientists at the DKFZ for the most part takes place in laboratories with different safety levels. What determines the identity of cells Scientists from the Hector Institute for Translational Brain Research and Stanford University showed in mice how so-called pioneer factors determine the identity of nerve and muscle cells. For this purpose, the stem cells simultaneously modify the blueprints for hundreds of proteins encoded in the gene transcripts. Due to the rapid spread of the coronavirus in Europe, cancer centers within a short period were faced with the challenge of minimizing the risk of infection for these patients while at the same time not compromising the provision of the necessary treatments. If this mechanism is inactivated, stem cells lose their self-renewal potential and can no longer react adequately to danger signals or inflammation. According to current opinion, chromothripsis occurs at the beginning of tumor development and plays an important role in cancer onset. Donate now. During embryonic development, these factors ensure that the various body cells can form. They use mini colons grown in the laboratory for their studies that allow them to work under conditions that are as similar as possible to those found in patients. In collaboration with colleagues from university hospitals in Heidelberg and Mannheim, DKFZ researchers are developing tests to detect the virus, carrying out research to develop a vaccine, and investigating how the virus causes very severe symptoms in some of those infected.{/INSERTKEYS}{/PARAGRAPH} A genetic defect that occurs in 15 percent of these children plays a key role by destabilizing the production and breakdown of proteins. The scientists perform a large number of parallel experiments on these "organoids", which improves the comparability of the results. In their commentary, the researchers discuss how to strike a good balance between maintaining and redefining research priorities. In this way, they control the amount of protein produced and can also control the formation of certain proteinisoforms. The researchers suspect that protein metabolism defects could be a previously underestimated cause of other types of cancer. With its "Proof of Concept" grants, the European Research Council ERC supports scientists to further develop the economic potential of their research results. Scientists at the German Cancer Research Center in Heidelberg DKFZ and the Mannheim Medical Faculty of the University of Heidelberg have succeeded in blocking this receptor with an antibody to thus prevent the growth of metastases in mice with breast or lung cancer. Press Releases. DKFZ spin-off provides app free of charge during corona crisis The current crises caused by the fast spread of covid is forcing clinics and its medical staff to take actions that otherwise would require months or years: Home office and the provision of mobile software solutions. For the duration of the crisis, the company makes the software available to doctors and hospitals free of charge. Women infected with high-risk types of human papillomavirus HPV have a high risk of developing cervical cancer. Suche nach Forschungsthemen. Both researchers want to advance the development of antibodies: as research reagents and for cancer prevention. A receptor in the cell layer that lines the blood vessels from the inside stimulates both the formation of new blood vessels in tumors and metastasis. Scientists from the German Cancer Research Center DKFZ and the University of Heidelberg's Medical Faculty Mannheim have examined tumor samples from patients and have discovered a potential new target for therapy and have discovered a potential new target for treatment, at least in a special group of melanoma patients whose tumor cells produce the growth factor angiopoietin The production of the growth factor in cancer cells was particularly evident in those melanomas that formed metastases. Medical images are visualized and communicated fast and secure providing the staff with a digital remote solution. In laboratory experiments, pioneer factors can even be used to transform cell types, for example skin cells into nerve cells. A test can help doctors to better assess this risk and identify those women who should be referred immediately for further diagnostic investigation. The researchers have thus made a crucial contribution to enhancing our understanding of metabolic syndrome and the development of diabetes. {PARAGRAPH}{INSERTKEYS}Chromothripsis is a form of genome instability by which one or a few chromosomes virtually "explode s " in a presumably single catastrophic event. In animal experiments, they have thus shown a new principle for slowing down the metastatic dissemination of cancer cells.